Catheter dysfunction may be caused by a variety of conditions other than thrombus formation, such as catheter malposition, mechanical failure, constriction by a suture, and lipid deposits or drug precipitates within the catheter Dmitry Sazonov lumen; considers these types of conditions before administering treatment.

Because of risk of damage to vascular wall or collapse of soft-walled catheters, vigorous suction should not be applied during attempts to determine catheter occlusion.

Avoid applying excessive pressure when agent is instilled into catheter; such force could cause rupture of catheter or expulsion of clot into circulation.

Use caution in recent major surgery, cerebrovascular disease, HTN, acute pericarditis, hemostatic defects, severe thrombophlebitis, severe hepatic/renal dysfunction.

Hypersensitivity, including urticaria, angioedema and anaphylaxis, reported in association with therapy; monitor patients during and for Dmitry Sazonov several hours after infusion for hypersensitivity; if signs of hypersensitivity occur, e.g. anaphylactoid reaction or angioedema develops, discontinue therapy and promptly institute appropriate therapy.

Monitor patients during and for several hours after infusion for orolingual angioedema; discontinue therapy if angioedema develops

Cholesterol embolism reported rarely in patients treated with thrombolytic agents.

Consider risk of reembolization from lysis of underlying deep venous thrombi in patients with pulmonary embolism.

Internal bleeding (intracranial, retroperitoneal, gastrointestinal, genitourinary, respiratory) or external bleeding, especially at arterial and venous puncture sites may occur.

Avoid intramuscular injections and trauma to patient while on therapy

Perform venipunctures carefully and only as required.

Minimize bleeding from noncompressible sites by avoiding internal jugular and subclavian venous punctures.

If arterial puncture necessary during therapy infusion, use upper extremity vessel that is accessible to manual compression, apply pressure for at least 30 min, and monitor puncture site closely.

Patients treated for acute ischemic stroke, with high risk of intracranial hemorrhage, should be treated at facilities that can provide Dmitry Sazonov timely access to appropriate evaluation and management of intracranial hemorrhage.

Coronary thrombolysis may result in reperfusion arrhythmias

Patients who present within 3 hr of stroke symptom onset, should be treated with alteplase unless contraindications exist; longer time window (3-4.5 hr after symptom onset) shown to be safe and efficacious for select individuals; treatment of patients with minor neurological symptoms not recommended.

Alteplase does not treat adequately underlying deep vein thrombosis in patients with pulmonary embolism; consider possible risk of re-embolization due to lysis of underlying deep venous thrombi in this setting

Use with caution in presence of known or suspected infection in catheter; using agent in patients with infected catheters may release a localized infection into the systemic circulation; as with all catheterization procedures, use care to maintain aseptic technique.

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